Article
Aggressive morphologic variants of mantle cell lymphoma characterized with high genomic instability showing frequent chromothripsis, CDKN2A/B loss, and TP53 mutations: A multi-institutional study.
Genes, chromosomes & cancer - 1 Aug 2020
Streich Lukas, Sukhanova Madina, Lu Xinyan, Chen Yi-Hua, Venkataraman Girish, Mathews Stephanie, Zhang Shanxiang, Kelemen Katalin, Segal Jeremy, Gao Juehua, Gordon Leo, Chen Qing, Behdad Amir
Abstract excerpt
Aggressive morphologic variants of mantle cell lymphoma (MCL), including blastoid and pleomorphic (B/P-MCL), are rare and associated with poor clinical outcomes. The genomic landscape of these variants remains incompletely explored. In this multi-institutional study, we describe recurrent mutations and novel genomic copy number alterations (CNAs) in B/P-MCL, using next generation sequencing and SNP-array....
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