Article
Blastoid and Pleomorphic Mantle Cell Lymphoma Demonstrate Distinct Clinicopathologic and Genetic Features.
The American journal of surgical pathology - 1 Aug 2023
Khanlari Mahsa, Mo Huan, Kim Do Hwan, Sakhdari Ali, Young Ken H, Jain Preetesh, Wang Michael, Li Shaoying, Kanagal-Shamanna Rashmi, Miranda Roberto N, Vega Francisco, Medeiros L Jeffrey, Ok Chi Young
Abstract excerpt
The blastoid (B) and pleomorphic (P) variants of mantle cell lymphoma (MCL) are associated with aggressive clinical behavior. In this study, we collected 102 cases of B-MCL and P-MCL from untreated patients. We reviewed clinical data, analyzed morphologic features using an image analysis tool (ImageJ) and we assessed mutational and gene expression profiles. The chromatin pattern of lymphoma cells was assessed...
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