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Article

Comparison of commercially available whole-genome sequencing kits for variant detection in circulating cell-free DNA.

Scientific reports - 10 Apr 2020

Mauger Florence, Horgues Caroline, Pierre-Jean Morgane, Oussada Nouara, Mesrob Lilia, Deleuze Jean-François

Abstract excerpt

Circulating cell-free DNA (ccfDNA) has great potential for non-invasive diagnosis, prognosis and monitoring treatment of disease. However, a sensitive and specific whole-genome sequencing (WGS) method is required to identify novel genetic variations (i.e., SNVs, CNVs and INDELS) on ccfDNA that can be used as clinical biomarkers. In this article, five WGS methods were compared: ThruPLEX Plasma-seq, QIAseq cfDNA...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 32277101
DOI: 10.1038/s41598-020-63102-8
PMCID: PMC7148341

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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