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Article

Whole genome sequencing of low input circulating cell-free DNA obtained from normal human subjects.

Physiological reports - 1 Aug 2021

Foley Julie F, Elgart Brian, Alex Merrick B, Phadke Dhiral P, Cook Molly E, Malphurs Jason A, Solomon Gregory G, Shah Ruchir R, Fessler Michael B, Miller Frederick W, Gerrish Kevin E

Abstract excerpt

Cell-free DNA circulates in plasma at low levels as a normal by-product of cellular apoptosis. Multiple clinical pathologies, as well as environmental stressors can lead to increased circulating cell-free DNA (ccfDNA) levels. Plasma DNA studies frequently employ targeted amplicon deep sequencing platforms due to limited concentrations (ng/ml) of ccfDNA in the blood. Here, we report whole genome sequencing (WGS)...

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Identifiers

PMID: 34350716
DOI: 10.14814/phy2.14993
PMCID: PMC8339531

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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