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Article

Whole exome sequencing of cell-free DNA - A systematic review and Bayesian individual patient data meta-analysis.

Cancer treatment reviews - 1 Feb 2020

Bos Manouk K, Angus Lindsay, Nasserinejad Kazem, Jager Agnes, Jansen Maurice P H M, Martens John W M, Sleijfer Stefan

Abstract excerpt

Molecular profiling of tumor derived cell free DNA (cfDNA) is gaining ground as a prognostic and predictive biomarker. However to what extent cfDNA reflects the full metastatic landscape as currently determined by tumor tissue analysis remains controversial. Though technically challenging, whole exome sequencing (WES) of cfDNA enables thorough evaluation of somatic alterations. Here, we review the feasibility of...

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Identifiers

PMID: 31874446
DOI: 10.1016/j.ctrv.2019.101951

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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