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Article

Study of Preanalytic and Analytic Variables for Clinical Next-Generation Sequencing of Circulating Cell-Free Nucleic Acid.

The Journal of molecular diagnostics : JMD - 1 Jul 2017

Mehrotra Meenakshi, Singh Rajesh R, Chen Wei, Huang Richard S P, Almohammedsalim Alaa A, Barkoh Bedia A, Simien Crystal M, Hernandez Marcos, Behrens Carmen, Patel Keyur P, Routbort Mark J, Broaddus Russell R, Medeiros L Jeffrey, Wistuba Ignacio I, Kopetz Scott, Luthra Rajyalakshmi

Abstract excerpt

Detection of mutations in plasma circulating cell-free DNA (cfDNA) by next-generation sequencing (NGS) has opened up new possibilities for monitoring treatment response and disease progression in patients with solid tumors. However, implementation of cfDNA genotyping in diagnostic laboratories requires systematic assessment of preanalytical parameters and analytical performance of NGS platforms. We assessed the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 28506684
DOI: 10.1016/j.jmoldx.2017.03.003

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KRAS

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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