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Comparison of Circulating Cell-Free DNA Extraction Methods for Downstream Analysis in Cancer Patients

13 May 2020

Abstract excerpt

Circulating cell-free DNA (ccfDNA) may contain DNA originating from the tumor in plasma of cancer patients (ctDNA) and enables noninvasive cancer diagnosis, treatment predictive testing, and response monitoring. A recent multicenter evaluation of workflows by the CANCER-ID consortium using artificial spiked-in plasma showed significant differences and consequently the importance of carefully selecting ccfDNA...

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PMID: 32414097
DOI: 10.3390/cancers12051222

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