Article
Association Analysis of Driver Gene-Related Genetic Variants Identified Novel Lung Cancer Susceptibility Loci with 20,871 Lung Cancer Cases and 15,971 Controls.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Jul 2020
Wang Yuzhuo, Gorlova Olga Y, Gorlov Ivan P, Zhu Meng, Dai Juncheng, Albanes Demetrius, Lam Stephen, Tardon Adonina, Chen Chu, Goodman Gary E, Bojesen Stig E, Landi Maria Teresa, Johansson Mattias, Risch Angela, Wichmann Heunz-Erich, Bickeboller Heike, Christiani David C, Rennert Gad, Arnold Susanne M, Brennan Paul, Field John K, Shete Sanjay, Le Marchand Loïc, Melander Olle, Brunnstrom Hans, Liu Geoffrey, Hung Rayjean J, Andrew Angeline S, Kiemeney Lambertus A, Zienolddiny Shanbeh, Grankvist Kjell, Johansson Mikael, Caporaso Neil E, Woll Penella J, Lazarus Philip, Schabath Matthew B, Aldrich Melinda C, Stevens Victoria L, Ma Hongxia, Jin Guangfu, Hu Zhibin, Amos Christopher I, Shen Hongbing
Abstract excerpt
BACKGROUND: A substantial proportion of cancer driver genes (CDG) are also cancer predisposition genes. However, the associations between genetic variants in lung CDGs and the susceptibility to lung cancer have rarely been investigated. METHODS: We selected expression-related single-nucleotide polymorphisms (eSNP) and nonsynonymous variants of lung CDGs, and tested their associations with lung cancer risk in two...
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