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Interaction analysis between germline susceptibility loci and somatic alterations in lung cancer.

International journal of cancer - 15 Aug 2018

Wang Yuzhuo, Wang Cheng, Zhang Jiahui, Zhu Meng, Zhang Xu, Li Zhihua, Dai Juncheng, Ma Hongxia, Hu Zhibin, Jin Guangfu, Shen Hongbing

Abstract excerpt

Emerging evidence indicates that germline variations may interact with somatic events in carcinogenesis. However, the germline-somatic interaction in lung cancer remains largely unknown. We investigated whether lung cancer driver genes (CDGs) were more likely to locate within cancer susceptibility regions. Pathway analysis was performed to identify common pathways underlying CDGs and cancer susceptibility genes...

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DNA-Binding Proteins
Genetic Loci
Genetic Predisposition to Disease
Germ-Line Mutation
Lung Neoplasms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Nuclear Proteins

Polymorphism, Single Nucleotide

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PMID: 29492964
DOI: 10.1002/ijc.31351

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