Article
Rare Variants in Known Susceptibility Loci and Their Contribution to Risk of Lung Cancer.
Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer - 1 Oct 2018
Liu Yanhong, Lusk Christine M, Cho Michael H, Silverman Edwin K, Qiao Dandi, Zhang Ruyang, Scheurer Michael E, Kheradmand Farrah, Wheeler David A, Tsavachidis Spiridon, Armstrong Georgina, Zhu Dakai, Wistuba Ignacio I, Chow Chi-Wan B, Behrens Carmen, Pikielny Claudio W, Neslund-Dudas Christine, Pinney Susan M, Anderson Marshall, Kupert Elena, Bailey-Wilson Joan, Gaba Colette, Mandal Diptasri, You Ming, de Andrade Mariza, Yang Ping, Field John K, Liloglou Triantafillos, Davies Michael, Lissowska Jolanta, Swiatkowska Beata, Zaridze David, Mukeriya Anush, Janout Vladimir, Holcatova Ivana, Mates Dana, Milosavljevic Sasa, Scelo Ghislaine, Brennan Paul, McKay James, Liu Geoffrey, Hung Rayjean J, Christiani David C, Schwartz Ann G, Amos Christopher I, Spitz Margaret R
Abstract excerpt
BACKGROUND: Genome-wide association studies are widely used to map genomic regions contributing to lung cancer (LC) susceptibility, but they typically do not identify the precise disease-causing genes/variants. To unveil the inherited genetic variants that cause LC, we performed focused exome-sequencing analyses on genes located in 121 genome-wide association study-identified loci previously implicated in the...
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