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Article

The rise of T-type channels in melanoma progression and chemotherapeutic resistance.

Biochimica et biophysica acta. Reviews on cancer - 1 Apr 2020

Alza Lía, Visa Anna, Herreros Judit, Cantí Carles

Abstract excerpt

Hyperactivation of the Mitogen Activated Protein Kinase (MAPK) pathway is prevalent in melanoma, principally due to mutations in the BRAF and NRAS genes. MAPK inhibitors are effective only short-term, and recurrence occurs due to functional redundancies or intertwined pathways. The remodeling of Ca2+ signaling is also common in melanoma cells, partly through the increased expression of T-type channels (TTCCs)....

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Identifiers

PMID: 32275934
DOI: 10.1016/j.bbcan.2020.188364

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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