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Article

Cross-talk between Dopachrome Tautomerase and Caveolin-1 Is Melanoma Cell Phenotype-specific and Potentially Involved in Tumor Progression.

The Journal of biological chemistry - 10 Jun 2016

Popa Ioana L, Milac Adina L, Sima Livia E, Alexandru Petruta R, Pastrama Florin, Munteanu Cristian V A, Negroiu Gabriela

Abstract excerpt

l-Dopachrome tautomerase (l-DCT), also called tyrosinase-related protein-2 (TRP-2), is a melanoma antigen overexpressed in most chemo-/radiotherapeutic stress-resistant tumor clones, and caveolin-1 (CAV1) is a main regulator of numerous signaling processes. A structural and functional relationship between DCT and CAV1 is first presented here in two human amelanotic melanoma cell lines, derived from vertical...

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Identifiers

PMID: 27053106
DOI: 10.1074/jbc.M116.714733
PMCID: PMC4933476

Genes

CAV1
DCT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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