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Article

Selected GRIN2A mutations in melanoma cause oncogenic effects that can be modulated by extracellular glutamate.

Cell calcium - 1 Dec 2016

D'mello Stacey Ann N, Joseph Wayne R, Green Taryn N, Leung Euphemia Y, During Matthew J, Finlay Graeme J, Baguley Bruce C, Kalev-Zylinska Maggie L

Abstract excerpt

GRIN2A mutations are frequent in melanoma tumours but their role in disease is not well understood. GRIN2A encodes a modulatory subunit of the N-methyl-d-aspartate receptor (NMDAR). We hypothesized that certain GRIN2A mutations increase NMDAR function and support melanoma growth through oncogenic effects. This hypothesis was tested using 19 low-passage melanoma cell lines, four of which carried novel missense...

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Identifiers

PMID: 27659111
DOI: 10.1016/j.ceca.2016.09.003

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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