Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Substrate structure and computation guided engineering of a lipase for omega-3 fatty acid selectivity.

PloS one - 1 Jan 2020

Moharana Tushar Ranjan, Rao Nalam Madhusudhana

Abstract excerpt

Enrichment of omega-3 fatty acids (ɷ-3 FAs) in natural oils is important to realize their health benefits. Lipases are promising catalysts to perform this enrichment, however, fatty acid specificity of lipases is poor. We attempted to improve the fatty acid selectivity of a lipase from Geobacillus thermoleovorans (GTL) by two approaches. In a semi-rational approach, amino acid positions critical for binding were...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amino Acids
Share to Catalytic Domain
Share to Fatty Acids, Omega-3

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Hydrolysis

Share to Lipase

Share to Methylation

Share to Mutant Proteins

Share to Protein Engineering

Source

Open in PubMed Open full text

Identifiers

PMID: 32271820
DOI: 10.1371/journal.pone.0231177
PMCID: PMC7145112

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Substrate structure and computation guided engineering of a lipase for omega-3 fatty acid selectivity.PMID 32271820Read ↗

Structure-guided modification of Rhizomucor miehei lipase for production of structured lipids.Semantic proximity Read ↗

Creation of a lipase highly selective for trans fatty acids by protein engineering.Semantic proximity Read ↗

Mutations in the Substrate-Binding Pocket of DiacylGlycerol Acyltransferase Alter the Fatty Acid Composition of Triacylglycerides in Yeast.Semantic proximity Read ↗

Targeted mutations and MD simulations of a methanol-stable lipase YLIP9 from Yarrowia lipolytica MSR80 to develop a biodiesel enzyme.Semantic proximity Read ↗

Structure of product-bound SMG1 lipase: active site gating implications.Semantic proximity Read ↗

Semi-rational engineering of CYP153A35 to enhance ω-hydroxylation activity toward palmitic acid.Semantic proximity Read ↗

Molecular and functional diversity of yeast and fungal lipases: their role in biotechnology and cellular physiology.Semantic proximity Read ↗

Rational creation of mutant enzyme showing remarkable enhancement of catalytic activity and enantioselectivity toward poor substrates.Semantic proximity Read ↗

Structure elucidation and docking analysis of 5M mutant of T1 lipase Geobacillus zalihae.Semantic proximity Read ↗

[Improving the thermal stability of Bacillus subtilis lipase based on multiple computational design strategies].Semantic proximity Read ↗

Identification of residues essential for differential fatty acyl specificity of Geotrichum candidum lipases I and II.Semantic proximity Read ↗

Predicting the impact of mutations on the specific activity of Bacillus thermocatenulatus lipase using a combined approach of docking and molecular dynamics.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.