Article
Mutations in the Substrate-Binding Pocket of DiacylGlycerol Acyltransferase Alter the Fatty Acid Composition of Triacylglycerides in Yeast.
ACS synthetic biology - 19 Sept 2025
Abdul Muthaliff Nazreen V M, Fitriani Nur Eka, Smith Derek, Ong Jing Sen, Yang Lay Kien, Busran Coleen Toledo, Thong Aaron, Arumugam Prakash, Sofeo Naazneen
Abstract excerpt
Triacylglycerols (TAGs) are the main components of food oils and fats. The fatty acid composition of TAGs varies for different oils and fats. Specific enzymes sequentially add three fatty acids to the glycerol backbone of TAGs. Diacylglycerol acyltransferase or DGAT adds the third and ultimate fatty acid to the glycerol backbone at the sn-3 position. In this study, we characterized the substrate-binding pocket of...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.