Structure of product-bound SMG1 lipase: active site gating implications.

Abstract excerpt

Monoacylglycerol and diacylglycerol lipases are industrially interesting enzymes, due to the health benefits that arise from the consumption of diglycerides compared to the traditional triglyceride oils. Most lipases possess an α-helix (lid) directly over the catalytic pocket which regulates the activity of the enzyme. Generally, lipases exist in active and inactive conformations, depending on the positioning of...

Topics

• Catalytic Domain
• Lipase
• Malassezia
• Models, Molecular
• Mutation
• Protein Conformation