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Article

Allelic Variation in the Toll-Like Receptor Adaptor Protein Ticam2 Contributes to SARS-Coronavirus Pathogenesis in Mice.

G3 (Bethesda, Md.) - 7 Jun 2017

Gralinski Lisa E, Menachery Vineet D, Morgan Andrew P, Totura Allison L, Beall Anne, Kocher Jacob, Plante Jessica, Harrison-Shostak D Corinne, Schäfer Alexandra, Pardo-Manuel de Villena Fernando, Ferris Martin T, Baric Ralph S

Abstract excerpt

Host genetic variation is known to contribute to differential pathogenesis following infection. Mouse models allow direct assessment of host genetic factors responsible for susceptibility to Severe Acute Respiratory Syndrome coronavirus (SARS-CoV). Based on an assessment of early stage lines from the Collaborative Cross mouse multi-parent population, we identified two lines showing highly divergent...

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Identifiers

PMID: 28592648
DOI: 10.1534/g3.117.041434
PMCID: PMC5473747

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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