Article

Dysregulation of innate immune signaling in animal models of Spinal Muscular Atrophy

2023-12-15

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> Spinal Muscular Atrophy (SMA) is a devastating neuromuscular disease caused by hypomorphic loss of function in the Survival Motor Neuron (SMN) protein. SMA presents across broad spectrum of disease severity. Unfortunately, vertebrate models of intermediate SMA have been difficult to generate and are thus unable to address key aspects of disease etiology. To address these iss...

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Literature Corpus work: ea080ff2-43df-5cc1-a56f-9a51ba7d20ec
DOI: 10.1101/2023.12.14.571739

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