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Article

A SARM1-mitochondrial feedback loop drives neuropathogenesis in a Charcot-Marie-Tooth disease type 2A rat model.

The Journal of clinical investigation - 1 Dec 2022

Sato-Yamada Yurie, Strickland Amy, Sasaki Yo, Bloom Joseph, DiAntonio Aaron, Milbrandt Jeffrey

Abstract excerpt

Charcot-Marie-Tooth disease type 2A (CMT2A) is an axonal neuropathy caused by mutations in the mitofusin 2 (MFN2) gene. MFN2 mutations result in profound mitochondrial abnormalities, but the mechanism underlying the axonal pathology is unknown. Sterile α and Toll/IL-1 receptor motif-containing 1 (SARM1), the central executioner of axon degeneration, can induce neuropathy and is activated by dysfunctional...

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Identifiers

PMID: 36287202
DOI: 10.1172/JCI161566
PMCID: PMC9711878

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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