Article
Structural morphing in a symmetry-mismatched viral vertex.
Nature communications - 6 Apr 2020
Fang Qianglin, Tang Wei-Chun, Tao Pan, Mahalingam Marthandan, Fokine Andrei, Rossmann Michael G, Rao Venigalla B
Abstract excerpt
Large biological structures are assembled from smaller, often symmetric, sub-structures. However, asymmetry among sub-structures is fundamentally important for biological function. An extreme form of asymmetry, a 12-fold-symmetric dodecameric portal complex inserted into a 5-fold-symmetric capsid vertex, is found in numerous icosahedral viruses, including tailed bacteriophages, herpesviruses, and archaeal...
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