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Article

Structural basis for genome packaging, retention, and ejection in human cytomegalovirus

27 Jul 2021

Abstract excerpt

How the human cytomegalovirus (HCMV) genome-the largest among human herpesviruses-is packaged, retained, and ejected remains unclear. We present the in situ structures of the symmetry-mismatched portal and the capsid vertex-specific components (CVSCs) of HCMV. The 5-fold symmetric 10-helix anchor-uncommon among known portals-contacts the portal-encircling DNA, which is presumed to squeeze the portal as the genome...

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PMID: 34315863
DOI: 10.1038/s41467-021-24820-3

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