Article
A structural model of the genome packaging process in a membrane-containing double stranded DNA virus.
PLoS biology - 1 Dec 2014
Hong Chuan, Oksanen Hanna M, Liu Xiangan, Jakana Joanita, Bamford Dennis H, Chiu Wah
Abstract excerpt
Two crucial steps in the virus life cycle are genome encapsidation to form an infective virion and genome exit to infect the next host cell. In most icosahedral double-stranded (ds) DNA viruses, the viral genome enters and exits the capsid through a unique vertex. Internal membrane-containing viruses possess additional complexity as the genome must be translocated through the viral membrane bilayer. Here, we...
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