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Human Enterovirus 71 Uncoating Captured at Atomic Resolution

19 Dec 2013

Abstract excerpt

UNLABELLED: Human enterovirus 71 (EV71) is the major causative agent of severe hand-foot-and-mouth diseases (HFMD) in young children, and structural characterization of EV71 during its life cycle can aid in the development of therapeutics against HFMD. Here, we present the atomic structures of the full virion and an uncoating intermediate of a clinical EV71 C4 strain to illustrate the structural changes in the...

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PMID: 24352461
DOI: 10.1128/jvi.03029-13

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