Article
Cryo-EM structure of the bacteriophage T4 isometric head at 3.3-Å resolution and its relevance to the assembly of icosahedral viruses.
Proceedings of the National Academy of Sciences of the United States of America - 26 Sept 2017
Chen Zhenguo, Sun Lei, Zhang Zhihong, Fokine Andrei, Padilla-Sanchez Victor, Hanein Dorit, Jiang Wen, Rossmann Michael G, Rao Venigalla B
Abstract excerpt
The 3.3-Å cryo-EM structure of the 860-Å-diameter isometric mutant bacteriophage T4 capsid has been determined. WT T4 has a prolate capsid characterized by triangulation numbers (T numbers) Tend = 13 for end caps and Tmid = 20 for midsection. A mutation in the major capsid protein, gp23, produced T=13 icosahedral capsids. The capsid is stabilized by 660 copies of the outer capsid protein, Soc, which clamp...
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