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Article

Endogenous Regulatory T Cells Promote M2 Macrophage Phenotype in Diabetic Stroke as Visualized by Optical Imaging.

Translational stroke research - 1 Feb 2021

Cai Yu, Xu Ting-Ting, Lu Chun-Qiang, Ma Yuan-Yuan, Chang Di, Zhang Yi, Gu Xiao-Chun, Ju Shenghong

Abstract excerpt

Regulatory T cells (Tregs) play an immunosuppressive role in various diseases, yet their function remains controversial in stroke and obscure in diabetic stroke. In the present study, Tregs were found downregulated in the peripheral blood of type 2 diabetes mellitus (T2DM) stroke models and patients compared with controls. In ischemic stroke mice (both T2DM and wild type), endogenous Tregs boosted by CD28SA...

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Source

Identifiers

PMID: 32240524
DOI: 10.1007/s12975-020-00808-x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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