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Article

TLR2 knockout protects against diabetes-mediated changes in cerebral perfusion and cognitive deficits.

American journal of physiology. Regulatory, integrative and comparative physiology - 1 Jun 2017

Hardigan Trevor, Hernandez Caterina, Ward Rebecca, Hoda M Nasrul, Ergul Adviye

Abstract excerpt

The risk of cognitive decline in diabetes (Type 1 and Type 2) is significantly greater compared with normoglycemic patients, and the risk of developing dementia in diabetic patients is doubled. The etiology for this is likely multifactorial, but one mechanism that has gained increasing attention is decreased cerebral perfusion as a result of cerebrovascular dysfunction. The innate immune system has been shown to...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 28336553
DOI: 10.1152/ajpregu.00482.2016
PMCID: PMC5495921

Genes

TLR2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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