Article
Islet transplantation modulates macrophage to induce immune tolerance and angiogenesis of islet tissue in type I diabetes mice model.
Aging - 20 Nov 2020
Li Yang, Ding Xiaoming, Tian Xiaohui, Zheng Jin, Ding Chenguang, Li Xiao, Hu Xiaojun, Qiao Yuxi, Wang Ying, Xue Wujun
Abstract excerpt
Objective To investigate the dual mechanism of islet transplantation in T1D by regulating the immune tolerance of macrophages and inducing the neovascularization. Methods NC group, T1D model group and T1D model + islet group were constructed. Then, the abdominal aorta blood of abdominal aorta and islet tissue were collected. ELISA was performed to detect the level of IL-1Rα, IL-1α, IL-1β, CXCL2, MCP1, TNF-α and...
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