Article

Recruitment of Regulatory T Cells with rCCL17 Promotes M2 Microglia/Macrophage Polarization Through TGFβ/TGFβR/Smad2/3 Pathway in a Mouse Model of Intracerebral Hemorrhage

2021-11-02

Abstract excerpt

<title>Abstract</title> <p>Background Intracerebral hemorrhage (ICH) is a devastating neurological disease with high mortality and morbidity. The microglia activation and peripheral inflammatory cells infiltration play an important role in the ICH prognosis. Previous studies have demonstrated that regulatory T cells (Tregs) ameliorated neuroinflammation following experimental ICH. However, the specific molecular...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 0f158f79-9183-5490-8af7-465fac316668
DOI: 10.21203/rs.3.rs-994135/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Recruitment of Regulatory T Cells with rCCL17 Promotes M2 Microglia/Macrophage Polarization Through TGFβ/TGFβR/Smad2/3 Pathway in a Mouse Model of Intracerebral HemorrhageDOI 10.21203/rs.3.rs-994135/v1Read

Regulatory T cells ameliorate intracerebral hemorrhage-induced inflammatory injury by modulating microglia/macrophage polarization through the IL-10/GSK3β/PTEN axis.Semantic proximity Read

Therapeutic Role of Microglia/Macrophage Polarization in Intracerebral HemorrhageSemantic proximity Read

Factors Regulating the Differences in Frequency of Infiltration of Th17 and Treg of the Blood-Brain BarrierSemantic proximity Read

Ex vivo Expanded Human Regulatory T Cells Modify Neuroinflammation in a Preclinical Model of Alzheimer’s diseaseSemantic proximity Read

New Insights into Roles of IL-7R Gene as a Therapeutic Target Following Intracerebral HemorrhageSemantic proximity Read

Irf8 exacerbates hypertensive intracerebral hemorrhage by mediating a pro-inflammatory phenotype of microglia through the Stat1/Trim5 axis.Semantic proximity Read

Enhancing Th17 cells drainage through meningeal lymphatic vessels alleviate neuroinflammation after subarachnoid hemorrhageSemantic proximity Read

Brain infiltrating T cells mediate microglial dysregulation and neuronal loss following SAHSemantic proximity Read

Alternatively activated brain-infiltrating macrophages facilitate recovery from collagenase-induced intracerebral hemorrhage.Semantic proximity Read

Regulatory T cells promote myelin regeneration in the central nervous systemSemantic proximity Read

MyD88-TLR4-dependent choroid plexus activation precedes perilesional inflammation and edema in intracerebral hemorrhageSemantic proximity Read

Tryptophan-rich diet and its effects on brain Tregs in alleviating neuroinflammation and cognitive impairmentSemantic proximity Read