Regulatory T cells ameliorate intracerebral hemorrhage-induced inflammatory injury by modulating microglia/macrophage polarization through the IL-10/GSK3β/PTEN axis.

doi:10.1177/0271678X16648712

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Article

Regulatory T cells ameliorate intracerebral hemorrhage-induced inflammatory injury by modulating microglia/macrophage polarization through the IL-10/GSK3β/PTEN axis.

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism - 1 Mar 2017

Zhou Kai, Zhong Qi, Wang Yan-Chun, Xiong Xiao-Yi, Meng Zhao-You, Zhao Ting, Zhu Wen-Yao, Liao Mao-Fan, Wu Li-Rong, Yang Yuan-Rui, Liu Juan, Duan Chun-Mei, Li Jie, Gong Qiu-Wen, Liu Liang, Yang Mei-Hua, Xiong Ao, Wang Jian, Yang Qing-Wu

Abstract excerpt

Inflammation mediated by the peripheral infiltration of inflammatory cells plays an important role in intracerebral hemorrhage (ICH) induced secondary injury. Previous studies have indicated that regulatory T lymphocytes (Tregs) might reduce ICH-induced inflammation, but the precise mechanisms that contribute to ICH-induced inflammatory injury remain unclear. Our results show that the number of Tregs in the brain...

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Identifiers

PMID: 27174997
DOI: 10.1177/0271678X16648712
PMCID: PMC5363473

Genes

PTEN
TNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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