Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Exendin-4 reduces ischemic brain injury in normal and aged type 2 diabetic mice and promotes microglial M2 polarization.

PloS one - 1 Jan 2014

Darsalia Vladimer, Hua Sansan, Larsson Martin, Mallard Carina, Nathanson David, Nyström Thomas, Sjöholm Åke, Johansson Maria E, Patrone Cesare

Abstract excerpt

Exendin-4 is a glucagon-like receptor 1 agonist clinically used against type 2 diabetes that has also shown neuroprotective effects in experimental stroke models. However, while the neuroprotective efficacy of Exendin-4 has been thoroughly investigated if the pharmacological treatment starts befo...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Brain Ischemia
Share to Diabetes Mellitus, Experimental
Share to Drug Evaluation, Preclinical

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Infarction, Middle Cerebral Artery

Share to Microglia

Share to Neuroprotective Agents

Share to Peptides

Share to Stroke

Source

Open in PubMed Open full text

Identifiers

PMID: 25101679
DOI: 10.1371/journal.pone.0103114
PMCID: PMC4125154

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-25101679-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Exendin-4 reduces ischemic brain injury in normal and aged type 2 diabetic mice and promotes microglial M2 polarization.PMID 25101679Read ↗

Treatment targets for M2 microglia polarization in ischemic stroke.Semantic proximity Read ↗

Muscone promotes functional recovery by facilitating microglia polarization into M2 phenotype through PPAR-γ pathway after ischemic stroke.Semantic proximity Read ↗

Microglia and Monocytes/Macrophages Polarization Reveal Novel Therapeutic Mechanism against Stroke.Semantic proximity Read ↗

Bone marrow mesenchymal stem cell-derived exosomes attenuate cerebral ischemia-reperfusion injury-induced neuroinflammation and pyroptosis by modulating microglia M1/M2 phenotypes.Semantic proximity Read ↗

Docosahexaenoic acid promotes M2 microglia phenotype via activating PPARγ-mediated ERK/AKT pathway against cerebral ischemia-reperfusion injury.Semantic proximity Read ↗

Exenatide reverts the high-fat-diet-induced impairment of BDNF signaling and inflammatory response in an animal model of Alzheimer’s diseaseSemantic proximity Read ↗

Delayed Treatment with Green Tea Polyphenol EGCG Promotes Neurogenesis After Ischemic Stroke in Adult Mice.Semantic proximity Read ↗

NLRP3 inflammasome inhibitor ameliorates ischemic stroke by reprogramming the phenotype of microglia/macrophage in a murine model of distal middle cerebral artery occlusion.Semantic proximity Read ↗

Netrin-1 controls inflammation in response to ischemic stroke through altering microglia phenotype.Semantic proximity Read ↗

Rhein Alleviates Cerebral Ischemia/Reperfusion Injury by Inhibiting the Microglial NLRP3 Inflammasome/Pyroptosis Axis and Regulating Microglial M1/M2 Phenotypes.Semantic proximity Read ↗

Hypothermia Protects Against Ischemic Stroke Through Peroxisome-proliferator-activated-receptor GammaSemantic proximity Read ↗

The novel Nrf2 activator CDDO-EA attenuates cerebral ischemic injury by promoting microglia/macrophage polarization toward M2 phenotype in mice.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.