Article
Parental-to-embryo switch of chromosome organization in early embryogenesis.
Nature - 1 Apr 2020
Collombet Samuel, Ranisavljevic Noémie, Nagano Takashi, Varnai Csilla, Shisode Tarak, Leung Wing, Piolot Tristan, Galupa Rafael, Borensztein Maud, Servant Nicolas, Fraser Peter, Ancelin Katia, Heard Edith
Abstract excerpt
Paternal and maternal epigenomes undergo marked changes after fertilization1. Recent epigenomic studies have revealed the unusual chromatin landscapes that are present in oocytes, sperm and early preimplantation embryos, including atypical patterns of histone modifications2-4 and differences in chromosome organization and accessibility, both in gametes5-8 and after fertilization5,8-10. However, these studies have...
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