Article

A microbial metabolite protects against graft-versus-host disease via mTORC1 and STING-dependent intestinal regeneration

2025-04-15

Abstract excerpt

<h4>Summary</h4> Changes in the intestinal microbiome and microbiota-derived metabolites predict clinical outcomes after allogeneic hematopoietic stem cell transplantation (allo-HSCT). Here, we report that desaminotyrosine (DAT), a product of bacterial flavonoid metabolism, correlates with improved overall survival and reduced relapse rates in allo-HSCT patients. In preclinical mouse models, treatment with synthe...

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Literature Corpus work: 2d227372-c63d-5d7b-869b-c7733f0c3361
DOI: 10.1101/2025.04.08.647747

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