Article

Chronic pancreatitis patient-derived organoids reveal new paths to precision therapeutics

2024-11-03

Abstract excerpt

<h4>Summary</h4> Chronic pancreatitis (CP) affects ∼3 million people worldwide, yet altering the course of disease is challenging. We developed a patient-derived organoid (PDO) platform to investigate the molecular pathogenesis of this disease and identify therapeutic strategies. We generated 36 PDOs from patients with idiopathic, hereditary, and alcohol-related CP with high genetic concordance. PDOs retained inf...

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Literature Corpus work: b70882eb-b6d1-5cb3-8e6f-b6028eb34465
DOI: 10.1101/2024.10.30.620903

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