Article

Integrative analysis of Paneth cell proteomic and transcriptomic data from intestinal organoids reveals functional processes dependent on autophagy

2018-09-05

Abstract excerpt

<h4>Summary statement</h4> Using an integrative approach encompassing intestinal organoid culture, proteomics, transcriptomics and protein-protein interaction networks, we list Paneth cell functions dependent on autophagy. Paneth cells are key epithelial cells providing an antimicrobial barrier and maintaining integrity of the small intestinal stem cell niche. Paneth cell abnormalities are unfortunately detriment...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: d75851b6-8519-54a6-9f68-c0523ef3ac5c
DOI: 10.1101/410027

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Integrative analysis of Paneth cell proteomic and transcriptomic data from intestinal organoids reveals functional processes dependent on autophagyDOI 10.1101/410027Read

A common role for Atg16L1, Atg5, and Atg7 in small intestinal Paneth cells and Crohn diseaseSemantic proximity Read

Intestinal Epithelium and Autophagy: Partners in Gut HomeostasisSemantic proximity Read

The emerging roles of autophagy in intestinal epithelial cells and its links to inflammatory bowel diseaseSemantic proximity Read

The role of autophagy in Paneth cell differentiation and secretion.Semantic proximity Read

Impact of Paneth Cell Autophagy on Inflammatory Bowel Disease.Semantic proximity Read

A key role for autophagy and the autophagy gene Atg16l1 in mouse and human intestinal Paneth cells.Semantic proximity Read

Harnessing single-cell genomics to improve the physiological fidelity of organoid-derived cell typesSemantic proximity Read

Paneth cells and innate mucosal immunitySemantic proximity Read

Regulatory network analysis of Paneth cell and goblet cell enriched gut organoids using transcriptomics approachesSemantic proximity Read

BECLIN-1 is Essential for the Maintenance of Gastrointestinal Epithelial Integrity by Regulating Endocytic Trafficking, F-actin Organization and Lysosomal FunctionSemantic proximity Read

Regulatory network analysis of Paneth cell and goblet cell enriched gut organoids using transcriptomics approachesSemantic proximity Read

A proximal-to-distal survey of healthy adult human small intestine and colon epithelium by single-cell transcriptomicsSemantic proximity Read