Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The male germline-specific protein MAPS is indispensable for pachynema progression and fertility

18 Feb 2021

Abstract excerpt

Significance During meiosis prophase I in mammals, a series of events occur, such as homologous recombination, DSB repair, crossover formation, XY body formation, and meiotic sex chromosome inactivation (MSCI). We report here that a male pachynema-specific (MAPS) protein is essential for prophase I progression in mouse spermatocytes. Maps knockout causes the demise of pachytene spermatocytes throughout early to...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
Share to Nuclear Structure and Function
Share to Reproductive Biology and Fertility

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 33602822
DOI: 10.1073/pnas.2025421118

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The male germline-specific protein MAPS is indispensable for pachynema progression and fertilityPMID 33602822Read ↗

SKP1 drives the prophase I to metaphase I transition during male meiosis.Semantic proximity Read ↗

Proteomic analysis of male 4C germ cell proteins involved in mouse meiosisSemantic proximity Read ↗

Genetic control of meiosis surveillance mechanisms in mammalsSemantic proximity Read ↗

A TOPBP1 allele causing male infertility uncouples XY silencing dynamics from sex body formation.Semantic proximity Read ↗

CLPP Depletion Causes Diplotene Arrest; Underlying Testis Mitochondrial Dysfunction Occurs with Accumulation of Perrault Proteins ERAL1, PEO1, and HARS2.Semantic proximity Read ↗

SHCBP1L, a conserved protein in mammals, is predominantly expressed in male germ cells and maintains spindle stability during meiosis in testisSemantic proximity Read ↗

A-MYB (MYBL1) transcription factor is a master regulator of male meiosis.Semantic proximity Read ↗

Maintenance DNA methylation in pre-meiotic germ cells regulates meiotic prophase by facilitating homologous chromosome pairingSemantic proximity Read ↗

Extensive meiotic asynapsis in mice antagonises meiotic silencing of unsynapsed chromatin and consequently disrupts meiotic sex chromosome inactivation.Semantic proximity Read ↗

VCP acts downstream of tTAFs to downregulate mono-ubiquitinated H2A and promote spermatocyte differentiation in <i>Drosophila</i>Semantic proximity Read ↗

HSF5 Deficiency Causes Male Infertility Involving Spermatogenic Arrest at Meiotic Prophase I in Humans and MiceSemantic proximity Read ↗

Meiosis I arrest abnormalities lead to severe oligozoospermia in meiosis 1 arresting protein (M1ap)-deficient mice.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.