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Article

The ATM signaling cascade promotes recombination-dependent pachytene arrest in mouse spermatocytes.

PLoS genetics - 1 Mar 2015

Pacheco Sarai, Marcet-Ortega Marina, Lange Julian, Jasin Maria, Keeney Scott, Roig Ignasi

Abstract excerpt

Most mutations that compromise meiotic recombination or synapsis in mouse spermatocytes result in arrest and apoptosis at the pachytene stage of the first meiotic prophase. Two main mechanisms are thought to trigger arrest: one independent of the double-strand breaks (DSBs) that initiate meiotic recombination, and another activated by persistent recombination intermediates. Mechanisms underlying the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 25768017
DOI: 10.1371/journal.pgen.1005017
PMCID: PMC4358828

Genes

ATM
TRIP13

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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