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Article

TERT promoter mutations are associated with poor prognosis and cell immortalization in meningioma.

Neuro-oncology - 12 Nov 2018

Spiegl-Kreinecker Sabine, Lötsch Daniela, Neumayer Katharina, Kastler Lucia, Gojo Johannes, Pirker Christine, Pichler Josef, Weis Serge, Kumar Rajiv, Webersinke Gerald, Gruber Andreas, Berger Walter

Abstract excerpt

Background: Meningiomas are mostly benign tumors tending to progress to higher-grade lesions. Mutations in the telomerase reverse transcriptase (TERT) gene promoter are comparably rare in meningioma, but were recently suggested to predict risk of recurrence and progression. Here we have analyzed a cohort of World Health Organization grades I-III meningiomas regarding the impact of TERT promoter mutations on...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 30010853
DOI: 10.1093/neuonc/noy104
PMCID: PMC6231195

Genes

TERT

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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