Article
An integrative multi-omics analysis to identify candidate DNA methylation biomarkers related to prostate cancer risk.
Nature communications - 6 Aug 2020
Wu Lang, Yang Yaohua, Guo Xingyi, Shu Xiao-Ou, Cai Qiuyin, Shu Xiang, Li Bingshan, Tao Ran, Wu Chong, Nikas Jason B, Sun Yanfa, Zhu Jingjing, Roobol Monique J, Giles Graham G, Brenner Hermann, John Esther M, Clements Judith, Grindedal Eli Marie, Park Jong Y, Stanford Janet L, Kote-Jarai Zsofia, Haiman Christopher A, Eeles Rosalind A, Zheng Wei, Long Jirong
Abstract excerpt
It remains elusive whether some of the associations identified in genome-wide association studies of prostate cancer (PrCa) may be due to regulatory effects of genetic variants on CpG sites, which may further influence expression of PrCa target genes. To search for CpG sites associated with PrCa risk, here we establish genetic models to predict methylation (N = 1,595) and conduct association analyses with PrCa...
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