Article
Expression QTL-based analyses reveal candidate causal genes and loci across five tumor types.
Human molecular genetics - 1 Oct 2014
Li Qiyuan, Stram Alexander, Chen Constance, Kar Siddhartha, Gayther Simon, Pharoah Paul, Haiman Christopher, Stranger Barbara, Kraft Peter, Freedman Matthew L
Abstract excerpt
The majority of trait-associated loci discovered through genome-wide association studies are located outside of known protein coding regions. Consequently, it is difficult to ascertain the mechanism underlying these variants and to pinpoint the causal alleles. Expression quantitative trait loci (eQTLs) provide an organizing principle to address both of these issues. eQTLs are genetic loci that correlate with RNA...
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