Article
Zebrafish Microenvironment Elevates EMT and CSC-Like Phenotype of Engrafted Prostate Cancer Cells.
Cells - 26 Mar 2020
Chen Lanpeng, Boleslaw Olszewski Maciej, Kruithof-de Julio Marianna, Snaar-Jagalska B Ewa
Abstract excerpt
To visually and genetically trace single-cell dynamics of human prostate cancer (PCa) cells at the early stage of metastasis, a zebrafish (ZF) xenograft model was employed. The phenotypes of intravenously transplanted fluorescent cells were monitored by high-resolution, single-cell intravital confocal and light-sheet imaging. Engrafted osteotropic, androgen independent PCa cells were extravasated from caudle...
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