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Mutant Kras-induced upregulation of CD24 enhances prostate cancer stemness and bone metastasis

22 Nov 2018

Abstract excerpt

Prostate cancer (PCA), one of the most common malignant tumors in men, is the second leading cause of cancer deaths in males worldwide. We report here that PCA models harboring conditional LSL/Kras G12D or BRAF F-V600E allele with prostate-specific abrogated p53 function recapitulate human PCA precursor lesions, histopathology, and clinical behaviors. We found that the development of reprogrammed EMT-like...

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PMID: 30467381
DOI: 10.1038/s41388-018-0575-7

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