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Article

Human prostate cancer metastases target the hematopoietic stem cell niche to establish footholds in mouse bone marrow

23 Mar 2011

Abstract excerpt

HSC homing, quiescence, and self-renewal depend on the bone marrow HSC niche. A large proportion of solid tumor metastases are bone metastases, known to usurp HSC homing pathways to establish footholds in the bone marrow. However, it is not clear whether tumors target the HSC niche during metastasis. Here we have shown in a mouse model of metastasis that human prostate cancer (PCa) cells directly compete with...

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PMID: 21436587
DOI: 10.1172/jci43414

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