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Article

PRKAR1A deficiency impedes hypertrophy and reduces heart size.

Physiological reports - 1 Mar 2020

Liu Yuening, Xia Peng, Chen Jingrui, Bandettini W Patricia, Kirschner Lawrence S, Stratakis Constantine A, Cheng Zhaokang

Abstract excerpt

Protein kinase A (PKA) activity is pivotal for proper functioning of the human heart, and its dysregulation has been implicated in a variety of cardiac pathologies. PKA regulatory subunit 1α (R1α, encoded by the PRKAR1A gene) is highly expressed in the heart, and controls PKA kinase activity by sequestering PKA catalytic subunits. Patients with PRKAR1A mutations are often diagnosed with Carney complex (CNC) in...

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Identifiers

PMID: 32212257
DOI: 10.14814/phy2.14405
PMCID: PMC7093752

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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