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Article

Differential role of PKA catalytic subunits in mediating phenotypes caused by knockout of the Carney complex gene Prkar1a.

Molecular endocrinology (Baltimore, Md.) - 1 Oct 2011

Yin Zhirong, Pringle Daphne R, Jones Georgette N, Kelly Kimberly M, Kirschner Lawrence S

Abstract excerpt

The Carney complex is an inherited tumor predisposition caused by activation of the cAMP-dependent protein kinase [protein kinase A (PKA)] resulting from mutation of the PKA-regulatory subunit gene PRKAR1A. Myxomas and tumors in cAMP-responsive tissues are cardinal features of this syndrome, which is unsurprising given the important role played by PKA in modulating cell growth and function. Previous studies...

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Identifiers

PMID: 21852354
DOI: 10.1210/me.2011-1008
PMCID: PMC3182421

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