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Article

The Carney complex gene PRKAR1A plays an essential role in cardiac development and myxomagenesis.

Trends in cardiovascular medicine - 1 Feb 2009

Yin Zhirong, Kirschner Lawrence S

Abstract excerpt

Cardiac myxomas are the most common primary tumors of the heart, although little is known about their etiology. Mutations of the protein kinase A regulatory subunit gene PRKAR1A cause inherited myxomas in the setting of the Carney complex tumor syndrome, providing a possible window for understanding their pathogenesis. We recently reported that cardiac-specific knockout of this gene causes myxomatous changes in...

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Share to Cell Transformation, Neoplastic
Share to Cyclic AMP
Share to Cyclic AMP-Dependent Protein Kinase RIalpha Subunit

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Regulation, Neoplastic

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Source

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Identifiers

PMID: 19577711
DOI: 10.1016/j.tcm.2009.04.005
PMCID: PMC2716068

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The Carney complex gene PRKAR1A plays an essential role in cardiac development and myxomagenesis.PMID 19577711Read ↗

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