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Article

Protein kinase-A activity in PRKAR1A-mutant cells, and regulation of mitogen-activated protein kinases ERK1/2.

Human molecular genetics - 1 Jul 2003

Robinson-White Audrey, Hundley Thomas R, Shiferaw Miriam, Bertherat Jérôme, Sandrini Fabiano, Stratakis Constantine A

Abstract excerpt

Carney complex (CNC) is caused by PRKAR1A-inactivating mutations. PRKAR1A encodes the regulatory subunit type I-alpha (RIalpha) of the cAMP-dependent kinase (PKA) holoenzyme; how RIalpha insufficiency leads to tumorigenesis remains unclear. In many cells PKA inhibits the extracellular receptor ki...

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PMID: 12812976
DOI: 10.1093/hmg/ddg160

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LPA

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-12812976-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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