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Article

Heart-Specific Ablation of <i>Prkar1a</i> Causes Failure of Heart Development and Myxomagenesis

4 Mar 2008

Abstract excerpt

BACKGROUND: Protein kinase A signaling has long been known to play an important role in cardiac function. Dysregulation of the protein kinase A system, caused by mutation of the protein kinase A regulatory subunit gene PRKAR1A, causes the inherited tumor syndrome Carney complex, which includes cardiac myxomas as one of its cardinal features. Mouse models of this genetic defect have been unsatisfactory because...

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PMID: 18316483
DOI: 10.1161/circulationaha.107.759233

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Heart-Specific Ablation of <i>Prkar1a</i> Causes Failure of Heart Development and MyxomagenesisPMID 18316483Read ↗

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