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Article

Arylsulfatase A, a genetic modifier of Parkinson’s disease, is an α-synuclein chaperone

1 Jul 2019

Abstract excerpt

Mutations in lysosomal genes increase the risk of neurodegenerative diseases, as is the case for Parkinson's disease. Here, we found that pathogenic and protective mutations in arylsulfatase A (ARSA), a gene responsible for metachromatic leukodystrophy, a lysosomal storage disorder, are linked to Parkinson's disease. Plasma ARSA protein levels were changed in Parkinson's disease patients. ARSA deficiency caused...

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PMID: 31312839
DOI: 10.1093/brain/awz205

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