Article
Loss of HtrA2/Omi activity in non-neuronal tissues of adult mice causes premature aging.
Cell death and differentiation - 1 Feb 2013
Kang S, Louboutin J-P, Datta P, Landel C P, Martinez D, Zervos A S, Strayer D S, Fernandes-Alnemri T, Alnemri E S
Abstract excerpt
mnd2 mice die prematurely as a result of neurodegeneration 30-40 days after birth due to loss of the enzymatic activity of the mitochondrial quality control protease HtrA2/Omi. Here, we show that transgenic expression of human HtrA2/Omi in the central nervous system of mnd2 mice rescues them from neurodegeneration and prevents their premature death. Interestingly, adult transgenic mnd2 mice develop accelerated...
Topics
- Aging, Premature
- Animals
- Autophagy
- Cardiomyopathies
- Central Nervous System
- DNA, Mitochondrial
- High-Temperature Requirement A Serine Peptidase 2
- Humans
- Mice
- Mice, Transgenic
- Mitochondrial Proteins