Article
Impaired membrane traffic in defective ether lipid biosynthesis.
Human molecular genetics - 15 Jan 2001
Thai T P, Rodemer C, Jauch A, Hunziker A, Moser A, Gorgas K, Just W W
Abstract excerpt
The first steps of ether lipid biosynthesis are exclusively localized to peroxisomes and hence some peroxisomal disorders are characterized by a severe deficiency of plasmalogens, the main ether lipids in humans. Here we report on gene defects of plasmalogen biosynthesis, chromosomal localization of the corresponding genes and, as a consequence of plasmalogen deficiency, on structural alterations of caveolae,...
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